5 Key Takeaways

• 1

  Early pars plana vitrectomy with ILM peeling offers durable visual and anatomic benefits for selected treatment-naïve DME patients.

• 2

  The VITAL Study followed 120 patients for 24 months, showing significant improvements in visual acuity and retinal thickness.

• 3

  Earlier intervention in DME patients is associated with better visual outcomes, with a 1.8% decrease in letter gain for each day of delay.

• 4

  OCT biomarkers like subretinal fluid and preserved IS/OS integrity are linked to favorable surgical outcomes in DME patients.

• 5

  PPV with ILM peeling should not replace anti-VEGF therapy but may be beneficial for patients unwilling to adhere to injection schedules.