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Article

Amplified HCQ Retinal Toxicity in a Patient With an LRAT Mutation

Case Study: A heterozygous LRAT mutation may have contributed to progressive retinal degeneration following HCQ exposure.

By: Mohan Bhadriraju, MD, Damla Oncel, MD, Mathew W. MacCumber, MD, PhD

Retinal Physician June 2, 2026

Top Institutions in Ophthalmology

Ranking combines internal corpus citation frequency with web search results due to limited internal data for this topic.

#1

Bascom Palmer Eye Institute

Miami, Florida
Bascom Palmer is ranked No. 1 in ophthalmology and has strong research programs in inherited retinal diseases and gene therapy.
Key Differentiators
- Ophthalmology
#2

Wills Eye Hospital

Philadelphia, Pennsylvania
Wills Eye Hospital is recognized for its large retina service and public guidance on HCQ safety.
Key Differentiators
- Ophthalmology
#3

American Academy of Ophthalmology

San Francisco, California
The Academy provides revised recommendations on screening for hydroxychloroquine retinopathy.
Key Differentiators
- Ophthalmology

Mohan Bhadriraju, MD

Specialties: Ophthalmology

Bio: Mohan Bhadriraju, MD, is a medical doctor specializing in ophthalmology with a focus on retinal diseases. He has contributed to research investigating the genetic and pharmacologic factors influencing retinal toxicity, including cases involving hydroxychloroquine retinal toxicity and mutations affecting the visual cycle enzyme LRAT. His work highlights the complex interaction between genetic predispositions and drug exposures in the pathophysiology of retinal disorders.

Damla Oncel, MD

Specialties: Ophthalmology

Bio: Damla Oncel, MD, is a medical doctor specializing in retinal diseases. She has contributed to research on hydroxychloroquine (HCQ)-associated retinal toxicity, particularly examining the genetic factors that may amplify risk, such as mutations in the LRAT gene involved in the visual cycle. Her work highlights the interaction between pharmacologic exposure to immunomodulating drugs and genetic predisposition to retinal degeneration. This focus situates her expertise within medical retina and genetic influences on ocular conditions.