Clinical Report: Retinal Disease Prevalence Study Reveals Gaps

Overview

A recent meta-analysis published in JAMA Ophthalmology quantified the prevalence of major retinal diseases in the U.S., revealing significant disparities by race, sex, and geography. The findings highlight a substantial health care burden associated with age-related macular degeneration, diabetic retinopathy, diabetic macular edema, and retinal vein occlusion.

Background

Understanding the prevalence of retinal diseases is crucial for healthcare planning and resource allocation. These conditions are leading causes of vision impairment, and disparities in prevalence can inform targeted interventions. The findings underscore the need for improved access to care, particularly for underrepresented populations.

Data Highlights

Key Findings

• Age-standardized prevalence of AMD was 6,104 in males vs 5,312 in females.
• DR prevalence was more than 2 times higher in Black vs White patients.
• DME prevalence was 4.6 times higher in Black vs White patients.
• State-level variation in AMD prevalence ranged from 3,497 to 7,214 per 100,000.
• Estimated annual payer costs were $13.41 billion for AMD and $6.23 billion for DR.

Clinical Implications

Healthcare providers should be aware of the significant disparities in retinal disease prevalence to better address the needs of diverse patient populations. Targeted screening and treatment strategies are essential to improve outcomes, particularly in high-prevalence groups.

Conclusion

The substantial prevalence of retinal conditions and associated disparities highlight the urgent need for enhanced healthcare access and resource planning to address these vision health challenges.

References

1. JAMA Ophthalmology, 2026 -- Prevalence and Health Care Disparities of Retinal Conditions: A Meta-Analysis
2. Retinal Physician — Analysis of Real-World Data Challenges Assumptions About IRD Penetrance
3. retinal physician — Analysis of Real-World Data Challenges Assumptions About IRD Penetrance
4. Ophthalmology Management — Survey Shows Significant Gap in Caregivers’ Understanding of Retinal Conditions
5. Retinal Physician — Clinical Trials in Pediatric Retinal Disease
6. Survey Shows Significant Gap in Caregivers’ Understanding of Retinal Conditions
7. Prevalence and Health Care Disparities of Retinal Conditions: A Meta-Analysis | JAMA Ophthalmology | JAMA Network
8. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2026 - PubMed
9. Faricimab Treat-and-Extend Dosing for Macular Edema Due to Retinal Vein Occlusion: 72-Week Results from the BALATON and COMINO Trials - PubMed