Five-Year Insights From the Pegcetacoplan Program

Lawrence J. Singerman, MD, FACS, reflects on clinical insights from the OAKS, DERBY, and GALE studies in geographic atrophy.

By: Lawrence J. Singerman, MD, FACS, Diana V. Do, MD

Retinal Physician June 24, 2026

-0:00/0:00

Lawrence J. Singerman

Principal Investigator, Retina Specialist

Specialties: Ophthalmology

Bio: Lawrence J. Singerman, MD, FACS, is a leading retina specialist known for his extensive work in retinal clinical trials, particularly in the area of geographic atrophy and novel therapies such as pegcetacoplan. He has served as a principal investigator in multiple pivotal clinical studies, including the phase 2 FILLY trial, phase 3 OAKS and DERBY studies, and the GALE extension study. Dr. Singerman is recognized for his leadership in advancing retinal therapeutics and has contributed important clinical insights into the treatment of retinal diseases. With over a decade of experience running an expanding retina clinical practice, Dr. Singerman mentors emerging retinal physicians and emphasizes the importance of clinical research in improving patient outcomes. His role at Clinical Trials at the Summit highlights his dedication to collaboration and knowledge-sharing among retina specialists and industry partners.

Diana V. Do, MD

Retina Specialist

Specialties: Ophthalmology

Bio: Diana V. Do, MD, is a retina specialist and author for Retinal Physician. Her work focuses on ophthalmology and retinal disease, with interest in clinical trials, practice management, and emerging therapies for retinal conditions. In her Retinal Physician column, Dr. Do discusses developments in retina care, including clinical research collaboration, international clinical trial infrastructure, and investigational treatments for neovascular age-related macular degeneration and diabetic macular edema. She has also referenced her training connections with the Wilmer Eye Institute.

PentaVision

Retinal Physician

Five-Year Insights From the Pegcetacoplan Program

Recommendations