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PentaVision

Retinal Physician

Article | 2026 ASRS Meeting

OTX-TKI: Inside the SOL-1 Data

At ASRS 2026, Dilsher S. Dhoot, MD, FASRS, shared additional phase 3 SOL-1 data on vision maintenance, rescue treatment, and safety with investigational OTX-TKI (Axpaxli) in neovascular AMD.

By: Dilsher S. Dhoot, MD
Retinal Physician July 20, 2026
5 Key Takeaways

  • 1

    The SOL-1 trial compared OTX-TKI (Axpaxli) to aflibercept (Eylea) in treatment-naïve patients with neovascular AMD.

  • 2

    The primary endpoint of vision maintenance was met with 74% of OTX-TKI patients maintaining vision compared to 56% for aflibercept.

  • 3

    At 52 weeks, 66% of OTX-TKI patients maintained vision, while 44% of those on aflibercept did.

  • 4

    30% of OTX-TKI patients required rescue treatment by week 52, compared to the same proportion in the aflibercept group by week 28.

  • 5

    OTX-TKI was found to be safe and well tolerated, with common adverse events similar to those expected from intravitreal injections.